Yes, there are some key differences in some areas and not so much in others. A glove's weight, the leather used, the webbing, the fit in the hand, break-in time, its ability to keep its shape, etc.
My favorite glove of all time was Zett -- a Japanese glovemaker who had a brief presence in the U.S. market back in the 1990s and was used by Mariano Rivera for a time. They had a 11-3/4 glove that I used in high school and college that kept its shape, was the perfect weight and leather. In pro ball, I used Rawlings supplied by my agent -- most players get their gloves from whichever manufacturer their agent has a partnership with. Some of the more recent Rawlings pro mesh gloves are awesome.